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MilliporeSigma™ APC4, Mouse, Unlabeled, Clone: CIV1.1,

Catalog No. MABS1257MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABS1257MI 100 μg Unconjugated
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Catalog No. MABS1257MI Supplier MilliporeSigma™ Supplier No. MABS1257

Description

Mouse Monoclonal Antibody

Anaphase-promoting complex subunit 4 (UniProt Q9UJX5; also known as APC4, Cyclosome subunit 4) is encoded by the ANAPC4 (also known as APC4) gene (Gene ID 29945) in human. APC4 is a component of the anaphase-promoting complex or cyclosome (APC/C). APC/C is an E3 ubiquitin ligase complex that promotes the transition from metaphase to anaphase of the cell cycle by targeting specific proteins for proteasomal degradation at specific times under the control of the spindle assembly checkpoint (SAC). The catalytic core of the APC/C consists of the cullin subunit APC2 and RING H2 domain subunit APC11. Other APC/C components, including APC4, are composed multiple repeat motifs with the main purpose of providing molecular scaffold support. APC4 contains WD repeats and has a molecular weight of approximately 92 kDa. APC4 is located in the nucleus during interphase and at the centrosome during metaphase/anaphase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APC4
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CIV1.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene ANAPC4, APC4
Gene Accession No. Q9UJX5
Host Species Mouse
Immunogen Linear peptide corresponding to human APC4 C-terminal end sequence.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NP_037499
Test Specificity Clone CIV1.1 target human APC4 C-terminal end sequence present in spliced isoforms 1 and 3, but absent in isoform 2 reported by UniProt (Q9UJX5).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1 κ
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For Research Use Only. Not for use in diagnostic procedures.

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