Invitrogen™ APC4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558373

Catalog No. PIPA558373

Description

Immunogen sequence: WLYVAMLRMT EDHVLPELNK MTQKDITFVA EFLTEHFNEA PDLYNRKGKY FNVERVGQYL KDEDDDLVSP PNTEGNQWYD FLQN Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: APC4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ANAPC4
• Gene Alias: 2610306D21Rik; ANAPC4; anaphase promoting complex subunit 4; anaphase-promoting complex subunit 4; APC4; cyclosome subunit 4; D5Ertd249e
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29945
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UJX5
• Gene Symbols: ANAPC4
• Immunogen: Recombinant protein corresponding to Human APC4. Recombinant protein control fragment (Product #RP-96598).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG