Invitrogen™ APC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583464

Catalog No. PIPA583464

Description

Immunogen sequence: LSQQASLLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AESKSNGEEG YGRSLR.

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome, a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein, compared to isoform a.

Specifications

• Antigen: APC5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Anapc5
• Gene Alias: 2510006G12Rik; AA408751; AA536819; AA986414; ANAPC5; anaphase promoting complex subunit 5; anaphase-promoting complex subunit 5; Anpc5; APC5; cyclosome subunit 5; MNCb-2778
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 288671, 51433, 59008
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A1L1K3, Q8BTZ4, Q9UJX4
• Gene Symbols: Anapc5
• Immunogen: Recombinant protein corresponding to Human ANAPC5. Recombinant protein control fragment (Product #RP-97657).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG