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Invitrogen™ APC5 Polyclonal Antibody
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Catalog No. PIPA583464
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100 μL
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PIPA583464 100 μL
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Catalog No. PIPA583464 Supplier Invitrogen™ Supplier No. PA583464
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LSQQASLLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AESKSNGEEG YGRSLR Highest antigen sequence indentity to the following orthologs: Rat - 98%, Mouse - 98%.

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome, a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein, compared to isoform a.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APC5
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Anapc5
Gene Accession No. A1L1K3, Q8BTZ4, Q9UJX4
Gene Alias 2510006G12Rik; AA408751; AA536819; AA986414; ANAPC5; anaphase promoting complex subunit 5; anaphase-promoting complex subunit 5; Anpc5; APC5; cyclosome subunit 5; MNCb-2778
Gene Symbols Anapc5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ANAPC5. Recombinant protein control fragment (Product #RP-97657).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288671, 51433, 59008
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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