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Invitrogen™ APC5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA583478

Catalog No. PIPA583478


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Description

Description

Immunogen sequence: ADGAILDKGR AMFLVAKCQV ASAASYDQPK KAEALEAAIE NLNEAKNYFA KVDCKERIRD VVYFQARLYH TLGKTQERNR CAMLFRQLHQ ELPS.

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome, a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein, compared to isoform a.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

APC5
Polyclonal
Unconjugated
Anapc5
2510006G12Rik; AA408751; AA536819; AA986414; ANAPC5; anaphase promoting complex subunit 5; anaphase-promoting complex subunit 5; Anpc5; APC5; cyclosome subunit 5; MNCb-2778
Rabbit
Antigen affinity chromatography
RUO
51433
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunocytochemistry
0.05 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9UJX4
Anapc5
Recombinant protein corresponding to Human ANAPC5. Recombinant protein control fragment (Product #RP-104708).
100 μL
Primary
Human
Antibody
IgG
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