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Invitrogen™ APC7 Polyclonal Antibody
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Catalog No. PIPA5114859
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100 μL
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PIPA5114859 100 μL
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Catalog No. PIPA5114859 Supplier Invitrogen™ Supplier No. PA5114859
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Apc7.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APC7
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene ANAPC7
Gene Accession No. Q9UJX3, Q9WVM3
Gene Alias Anapc7; anaphase promoting complex subunit 7; anaphase-promoting complex subunit 7; APC7; AW545589; Cyclosome subunit 7; prediabetic NOD sera-reactive autoantigen; si:ch211-127h20.1
Gene Symbols ANAPC7
Host Species Rabbit
Immunogen A synthesized peptide derived from human ANAPC7(Accession Q9UJX3), corresponding to amino acid residues 536-550.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 304490, 51434, 56317
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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