APCL/APC2 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2276	100 μL

Catalog No. 50-198-2276 Supplier Bioss Supplier No. BS12485R

Description

Rabbit Polyclonal Antibody

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.

Specifications

• Antigen: APCL/APC2
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: APC2
• Gene Accession No.: O95996
• Gene Alias: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; AI852447; APC2; APC2, WNT signaling pathway regulator; APCL; APC-like; R75424
• Gene Symbols: APC2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human APCL/APC2.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10297
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG