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Invitrogen™ APH1 Polyclonal Antibody
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Catalog No. PIPA518739
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100 μg
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Catalog No. Quantity
PIPA518739 100 μg
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Catalog No. PIPA518739 Supplier Invitrogen™ Supplier No. PA518739
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APH1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene APH1A
Gene Accession No. Q96BI3
Gene Alias 6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1; APH-1; aph-1 homolog A, gamma secretase subunit; aph-1 homolog A, gamma-secretase subunit; Aph1a; APH-1a; APH1A gamma secretase subunit; Aph-1alpha; CGI-78; Gamma-secretase subunit APH-1A; hypothetical protein LOC539247; presenilin-stabilization factor; PSF; RGD1311546; RP4-790G17.3; UNQ579/PRO1141
Gene Symbols APH1A
Host Species Goat
Immunogen Synthetic peptide sequence (HVTDRSDARLQYG) corresponding to the internal amino acids of APH1A (aa 58-71).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51107
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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