Invitrogen™ APH1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520317

Catalog No. PIPA520317

Description

Despite its predicted molecular weight, APH1 often migrates at aberrant locations in SDS-PAGE. A suggested positive control is RAW264.7 cell lysate. PA5-20317 can be used with blocking peptide PEP-0437.

APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Specifications

• Antigen: APH1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APH1A
• Gene Alias: 6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; anterior pharynx defective 1a homolog (C. elegans); APH1; APH-1; aph-1 homolog A, gamma secretase subunit; aph-1 homolog A, gamma-secretase subunit; Aph1a; APH-1a; APH1A gamma secretase subunit; Aph-1alpha; CGI-78; Gamma-secretase subunit APH-1A; hypothetical protein LOC539247; presenilin-stabilization factor; PSF; RGD1311546; RP4-790G17.3; UNQ579/PRO1141
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 226548, 51107
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8BVF7, Q96BI3
• Gene Symbols: APH1A
• Immunogen: A 13 amino acid peptide from near the amino terminus of human APH1a.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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