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Invitrogen™ APIP Polyclonal Antibody
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Catalog No. PIPA5121067
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PIPA5121067 100 μL
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Catalog No. PIPA5121067 Supplier Invitrogen™ Supplier No. PA5121067
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Description

Rabbit Polyclonal Antibody

Positive test controls include: 22Rv1, Mouse pancreas, Mouse stomach, Mouse heart, Mouse liver, Rat stomach. The target is usually found in the following locations: Cytoplasm. Immunogen sequence: MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP SGVQKERIQP EDMFVCDINE KDISGPSPSK KLKKSQCTPL FMNAYTMRGA GAVIHTHSKA AVMATLLFPG REFKITHQEM IKGIKKCTSG GYYRYDDMLV VPIIENTPEE KDLKDRMAHA MNEYPDSCAV LVRRHGVYVW GETWEKAKTM CECYDYLFDI AVSMKKVGLD PSQLPVGENG IV.

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APIP
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.85 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene APIP
Gene Accession No. Q96GX9, Q9WVQ5
Gene Alias APAF1 interacting protein; APAF1-interacting protein; APIP; APIP2; CG129; CGI29; CGI-29; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; Mmrp19; monocyte macrophage 19; monocyte/macrophage protein 19; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase; RGD1564562
Gene Symbols APIP
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human APIP (NP_057041.2).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 295961, 51074, 56369
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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