Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ APOBEC3G Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110643

Catalog No. PIPA5110643


Only null left
Add to Cart

Description

Description

Immunogen sequence: MHNDTWVLLN QRRGFLCNQA PHKHGFLEGR HAELCFLDVI PFWKLDLDQD YRVTCFTSWS PCFSCAQEMA KFISKNKHVS LCIFTARIYD DQGRCQEGLR TLAEAGAKIS IMTYSEFKHC WDTFVDHQGC PFQPWDGLDE HSQDLSGRL.

The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5-a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

APOBEC3G
Polyclonal
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q9HC16
APOBEC3G
Recombinant Protein corresonding to Human APOBEC3G. Recombinant protein control fragment (Product #RP-91476).
100 μL
Primary
Human
Antibody
IgG
Immunohistochemistry (Paraffin)
Unconjugated
APOBEC3G
A3G; APOBEC3G; APOBEC-related cytidine deaminase; APOBEC-related protein; APOBEC-related protein 9; apolipoprotein B editing enzyme catalytic polypeptide-like 3G; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3G; apolipoprotein B mRNA editing enzyme catalytic subunit 3G; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G; ARCD; ARP9; ARP-9; ASGPR2; ASGP-R2; bK150C2.7; CEM15; CEM-15; CLEC4H2; Deoxycytidine deaminase; dJ494G10.1; DNA dC->dU editing enzyme; DNA dC->dU-editing enzyme APOBEC-3G; FLJ12740; HBXBP; HL-2; MDS019; OTTHUMP00000028911; phorbolin-like protein MDS019
Rabbit
Antigen Affinity Chromatography
RUO
60489
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.