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Invitrogen™ APOBEC3H Polyclonal Antibody
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Catalog No. PIPA568166
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100 μL
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PIPA568166 100 μL
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Catalog No. PIPA568166 Supplier Invitrogen™ Supplier No. PA568166
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Description

Rabbit Polyclonal Antibody

APOBEC3H Polyclonal Antibody for Western Blot

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APOBEC3H
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene APOBEC3H
Gene Accession No. Q6NTF7
Gene Alias A3H; APOBEC3H; APOBEC-related protein 10; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; ARP10; ARP-10; DNA dC->dU-editing enzyme APOBEC-3H
Gene Symbols APOBEC3H
Host Species Rabbit
Immunogen Synthesized peptide derived from human APOBEC3H.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 164668
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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