APOBEC3H Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5103787

Catalog No. PIPA5103787

Description

Antibody detects endogenous levels of total APOBEC3H.

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Specifications

• Antigen: APOBEC3H
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APOBEC3H
• Gene Alias: A3H; APOBEC3H; APOBEC-related protein 10; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; ARP10; ARP-10; DNA dC->dU-editing enzyme APOBEC-3H
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 164668
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6NTF7
• Gene Symbols: APOBEC3H
• Immunogen: A synthesized peptide derived from human APOBEC3H(Accession Q6NTF7), corresponding to amino acid residues N147-D197.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov