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Invitrogen™ APOBEC3H Polyclonal Antibody
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Catalog No. PIPA554426
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100 μL
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PIPA554426 100 μL
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Catalog No. PIPA554426 Supplier Invitrogen™ Supplier No. PA554426
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CSSCAWELVD FIKAHDHLNL GIFASRLYYH WCKPQQKGLR LLCGSQVPVE VMGFPEFADC WENFVDHEKP LSFNPYKMLE ELDKNSRAIK RRLERIKQS Highest antigen sequence identity to the following orthologs: Mouse - 48%, Rat - 51%.

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen APOBEC3H
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.20 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene APOBEC3H
Gene Accession No. Q6NTF7
Gene Alias A3H; APOBEC3H; APOBEC-related protein 10; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; apolipoprotein B mRNA editing enzyme catalytic subunit 3H; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; ARP10; ARP-10; DNA dC->dU-editing enzyme APOBEC-3H
Gene Symbols APOBEC3H
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human APOBEC3H. Recombinant protein control fragment (Product #RP-92353).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 164668
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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