Invitrogen™ ApoC3 Recombinant Rabbit Monoclonal Antibody (6H21L11)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 701238

Catalog No. PI701238

Description

This antibody is predicted to react with mouse, non-human primate and rabbit based on sequence homology. Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.

Specifications

• Antigen: ApoC3
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P02656, P06759
• Gene Symbols: APOC3
• Immunogen: Peptide corresponding to amino acids 37-48 of human Apolipoprotein C3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry
• Clone: 6H21L11
• Conjugate: Unconjugated
• Gene: APOC3
• Gene Alias: Apoc3; APOCIII; Apo-CIII; apoC-III; Apolipoprotein; Apolipoprotein C3; apolipoprotein C-3; apolipoprotein C-III; HALP2; MGC150353
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 24207, 345
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid