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PeproTech ApoE3 Polyclonal Antibody, PeproTech®, Invitrogen™

Catalog No. 500P238100
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500P238100 100 μg
500P23850UG 50 μg
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Catalog No. 500P238100 Supplier PeproTech Supplier No. 500P238100UG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Huma ApoE3. Anti-Human ApoE3-specific antibody was purified by affinity chromatography employing an immobilized Human ApoE3 matrix. Sandwich ELISA: To detect Human ApoE3 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human ApoE3 (500-P238Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human ApoE3. Western Blot: To detect Human ApoE3 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human ApoE3 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ApoE3
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene APOE
Gene Accession No. P02649
Gene Alias ApoE
Gene Symbols APOE
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human ApoE3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 348
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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