Apolipoprotein J Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS1354R

Catalog No. 50-198-2966

Description

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

Specifications

• Antigen: Apolipoprotein J
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Clu
• Gene Alias: AAG4; Aging-associated gene 4 protein; aging-associated protein 4; AI893575; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J a; Apo J ß; Apo Ja; Apo Jb; APOJ; Apo-J; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ a; ApoJ ß; ApoJa; ApoJalpha; ApoJb; ApoJbeta; Apolipoprotein J; CLI; CLU; CLU1; CLU2; Clusterin; Clusterin alpha chain; Clusterin beta chain; Clustrin; Complement cytolysis inhibitor; Complement cytolysis inhibitor a chain; Complement cytolysis inhibitor b chain; complement lysis inhibitor; Complement-associated protein SP-40,40; D14Ucla3; DAG; Dimeric acid glycoprotein; HGNC:2095; Ku70-binding protein 1; KUB1; MGC24903; Msgp-2; NA1/NA2; RATTRPM2B; SGP2; SGP-2; SP40; SP-40; Sugp-2; Sulfated glycoprotein 2; testosterone repressed prostate message; Testosterone repressed prostate message 2; testosterone repressed prostate message-2; testosterone-repressed prostate message; Testosterone-repressed prostate message 2; testostrone-repressed prostate message 2; Trpm2; TRPM-2; TRPM2B; Trpmb
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1191
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P10909
• Gene Symbols: Clu
• Immunogen: KLH conjugated synthetic peptide derived from human Apolipoprotein J.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG