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Invitrogen™ Apoptosis-Enhancing Nuclease Polyclonal Antibody
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Catalog No. PIPA5111279
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100 μL
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PIPA5111279 100 μL
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Catalog No. PIPA5111279 Supplier Invitrogen™ Supplier No. PA5111279
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLTIPNAKDV LRKRHKRRSR QHQRFMARKA LLQEQGLLSM PPEPGSSPLP TPFGAATATE AASSGKQCLR AGSGSAP Highest antigen sequence indentity to the following orthologs: Rat - 62%, Mouse - 62%.

Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Apoptosis-Enhancing Nuclease
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AEN
Gene Accession No. Q8WTP8
Gene Alias 2700083B06Rik; AEN; aen {ECO:0000250; apoptosis enhancing nuclease; apoptosis-enhancing nuclease; apoptosis-enhancing nuclease {ECO:0000250; interferon stimulated exonuclease gene 20kDa-like 1; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1; interferon-stimulated 20 kDa exonuclease-like 1 {ECO:0000312; ISG20L1; pp12744; RGD:1305051}; RGD1305051; SBBI58; UniProtKB:Q8WTP8}
Gene Symbols AEN
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human Apoptosis-Enhancing Nuclease. Recombinant protein control fragment (Product #RP-98170).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64782
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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