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Invitrogen™ Apoptosis-Enhancing Nuclease Polyclonal Antibody
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Catalog No. PIPA522208
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100 μL
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PIPA522208 100 μL
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Catalog No. PIPA522208 Supplier Invitrogen™ Supplier No. PA522208
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, HepG2, Molt-4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Apoptosis-Enhancing Nuclease
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.9 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene AEN
Gene Accession No. Q8WTP8
Gene Alias 2700083B06Rik; AEN; aen {ECO:0000250; apoptosis enhancing nuclease; apoptosis-enhancing nuclease; apoptosis-enhancing nuclease {ECO:0000250; interferon stimulated exonuclease gene 20kDa-like 1; interferon stimulated exonuclease gene 20-like 1; interferon-stimulated 20 kDa exonuclease-like 1; interferon-stimulated 20 kDa exonuclease-like 1 {ECO:0000312; ISG20L1; pp12744; RGD:1305051}; RGD1305051; SBBI58; UniProtKB:Q8WTP8}
Gene Symbols AEN
Host Species Rabbit
Immunogen Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Apoptosis-enhancing nuclease. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64782
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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