APRIL Monoclonal Antibody (Sacha-1), Invitrogen™

Rat Monoclonal Antibody

Supplier:  Thermo Scientific MA121169

Catalog No. PIMA121169

Description

MA1-21169 detects APRIL in Human and Mouse samples. MA1-21169 has been successfully used in FACS and immunocytochemistry procedures. MA1-21169 immunogen is a recombit fusion protein of resideus 105-250 of human APRIL fused to residues 16-108 of human headless ACRP30

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for A PRoliferation-Inducing Ligand), TALL2 (for TNF and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative of BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.

Specifications

• Antigen: APRIL
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Gene: TNFSF13
• Gene Alias: APRIL, CD256, TALL2, TRDL-1, UNQ383/PRO715, TNFSF13
• Host Species: Rat
• Purification Method: Size-exclusion - Gel filtration
• Regulatory Status: RUO
• Gene ID (Entrez): 69583, 8741
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
• Clone: Sacha-1
• Conjugate: Unconjugated
• Gene Accession No.: O75888, Q9D777
• Gene Symbols: TNFSF13
• Immunogen: Recombit fusion protein of resideus 105-250 of human APRIL fused to residues 16-108 of human headless ACRP30
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a