Invitrogen™ Aquaporin 0 Polyclonal Antibody

Catalog No.	Quantity
PIPA5120840	100 μL

Catalog No. PIPA5120840 Supplier Invitrogen™ Supplier No. PA5120840

Description

Rabbit Polyclonal Antibody

Positive test controls include: HepG2, U-251MG, Mouse skeletal muscle, Mouse heart, Mouse liver, Mouse testis, Mouse eye, Rat eye. The target is usually found in the following locations: Cell junction, Cell membrane, Multi-pass membrane protein, gap junction. Immunogen sequence: LALATLVQSV GHISGAHVNP AVTFAFLVGS QMSLLRAFCY MAAQLLGAVA GAAVLYSVTP PAVRGNLALN TLHPAVSVGQ ATTVEIFLTL QFVLCIFATY D.

AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.

Specifications

• Antigen: Aquaporin 0
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.83 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MIP
• Gene Accession No.: P09011, P30301, P51180
• Gene Alias: AQP0; aquaporin 0; Aquaporin0; aquaporin-0; Cat; CTRCT15; dominant cataract; Hfi; hydropic fibers; lens fiber major intrinsic protein; lens opacity; LIM1; Lop; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; MIP; MIP26; MP26; Palm; shrivelled; Svl
• Gene Symbols: MIP
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MIP (NP_036196.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17339, 25480, 4284
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG