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Invitrogen™ Aquaporin 0 Polyclonal Antibody
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Catalog No. PIPA536535
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100 μL
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Catalog No. Quantity
PIPA536535 100 μL
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Catalog No. PIPA536535 Supplier Invitrogen™ Supplier No. PA536535
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 28 kDa. Purity is >95% by SDS-PAGE.

AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aquaporin 0
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene MIP
Gene Accession No. P09011, P30301, P51180
Gene Alias AQP0; aquaporin 0; Aquaporin0; aquaporin-0; Cat; CTRCT15; dominant cataract; Hfi; hydropic fibers; lens fiber major intrinsic protein; lens opacity; LIM1; Lop; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; MIP; MIP26; MP26; Palm; shrivelled; Svl
Gene Symbols MIP
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 110-160 of human AQP0.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17339, 25480, 4284
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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