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Invitrogen™ Aquaporin 0 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA536535
Description
This antibody detects endogenous protein at a molecular weight of 28 kDa. Purity is >95% by SDS-PAGE.
AQP0 is the most abundant endogenous protein in the plasma membrane of lens fiber cells where it functions not only as a water pore, but it is also involved in fiber-fiber adhesion and is crucial for fiber cell structure and organization. AQP0 contains an additional pore constriction, not seen in any other aquaporin structures, which may be responsible for pore gating. The closed AQP0 pore holds just three water molecules, which are spaced too far apart to form hydrogen bonds with each other. The C-terminal domain of AQP0 undergoes extensive post-translational modification, including many truncations, during lens aging due to the actions of m-calpain, proteases or non-enzymatic mechanisms. These truncation sites may be involved in the development of cataracts.
Specifications
Aquaporin 0 | |
Polyclonal | |
Unconjugated | |
MIP | |
AQP0; aquaporin 0; Aquaporin0; aquaporin-0; Cat; CTRCT15; dominant cataract; Hfi; hydropic fibers; lens fiber major intrinsic protein; lens opacity; LIM1; Lop; major intrinsic protein of eye lens fiber; major intrinsic protein of lens fiber; MIP; MIP26; MP26; Palm; shrivelled; Svl | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
17339, 25480, 4284 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.2 | |
P09011, P30301, P51180 | |
MIP | |
Synthetic peptide corresponding to amino acids 110-160 of human AQP0. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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