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Invitrogen™ Aquaporin 12 Polyclonal Antibody
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Catalog No. PIPA559918
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100 μL
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PIPA559918 100 μL
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Catalog No. PIPA559918 Supplier Invitrogen™ Supplier No. PA559918
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FQRNLFYGQK NKYRAPRGKP APASGDTQTP AKGSSVREPG RSGVE Highest antigen sequence identity to the following orthologs: Mouse - 42%, Rat - 40%.

Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO). No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aquaporin 12
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AQP12B
Gene Accession No. A6NM10, Q8IXF9
Gene Alias AQP12; AQP-12; AQP12A; AQP12B; AQP-12B; AQPX2; aquaporin 12; aquaporin 12A; aquaporin 12B; aquaporin X2; aquaporin-12; aquaporin-12A; Aquaporin-12B; INSSA3; insulin synthesis associated 3; RGD1562727
Gene Symbols AQP12A, AQP12B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Aquaporin 12. Recombinant protein control fragment (Product #RP-104335).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 375318, 653437
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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