Invitrogen™ Aquaporin 12 Polyclonal Antibody

Catalog No.	Quantity
PIPA5101434	100 μL

Catalog No. PIPA5101434 Supplier Invitrogen™ Supplier No. PA5101434

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total AQP12.

Aquaporin 12 (AQP12) is the most recently identified member of the mammalian AQP family and is specifically expressed in pancreatic acinar cells. In vitro expression studies have revealed that AQP12 is localized at intracellular sites. To determine the physiological roles of AQP12 in the pancreas, we generated knockout mice for this gene (AQP12-KO). No obvious differences were observed under normal conditions between wild-type (WT) and AQP12-KO mice in terms of growth, blood chemistry, pancreatic fluid content, or histology. However, when we induced pancreatitis through the administration of a cholecystokinin-8 (CCK-8) analog, the AQP12-KO mice showed more severe pathological damage to this organ than WT mice.

Specifications

• Antigen: Aquaporin 12
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: AQP12B
• Gene Accession No.: A6NM10, Q8IXF9
• Gene Alias: AQP12; AQP-12; AQP12A; AQP12B; AQP-12B; AQPX2; aquaporin 12; aquaporin 12A; aquaporin 12B; aquaporin X2; aquaporin-12; aquaporin-12A; Aquaporin-12B; INSSA3; insulin synthesis associated 3; RGD1562727
• Gene Symbols: AQP12A, AQP12B
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human AQP12A(Accession Q8IXF9), corresponding to amino acid residues V232-R282.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 375318, 653437
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG