AR Mouse anti-Human, Clone: AR441, Abnova™

Mouse monoclonal antibody raised against synthetic peptide of human AR.

Supplier:  Abnova Corporation MAB13321

Catalog No. 89-933-580

Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]

Sequence: STEDTAEYSPFKGGYTK

Specifications

• Antigen: AR
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Gene Alias: AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM
• Host Species: Mouse
• Purification Method: Protein A/G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 367
• Content And Storage: Store at 4°C.
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Clone: AR441
• Description: Mouse monoclonal antibody raised against synthetic peptide of human AR.
• Formulation: In 1mM PBS (0.05% BSA, 0.05% sodium azide).
• Gene Symbols: AR
• Immunogen: A synthetic peptide corresponding to amino acids 300-316 of human AR.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid