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AR Mouse anti-Human, Clone: AR441, Abnova™

Mouse monoclonal antibody raised against synthetic peptide of human AR.

Manufacturer:  Abnova Corporation MAB13321

Catalog No. 89-933-580


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Description

Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]

Sequence: STEDTAEYSPFKGGYTK
Specifications

Specifications

AR
AR441
Mouse monoclonal antibody raised against synthetic peptide of human AR.
In 1mM PBS (0.05% BSA, 0.05% sodium azide).
AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM
Mouse
IgG1, kappa
100 ug
Store at 4°C.
Monoclonal
Human
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
AR
A synthetic peptide corresponding to amino acids 300-316 of human AR.
Protein A/G purification
RUO
Primary
367
SDS
Documents
Product Certifications
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