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AR Mouse anti-Human, Clone: SPM335, Abnova™

Catalog No. 89933582 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-933-582 100 μg
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Catalog No. 89-933-582 Supplier Abnova Corporation Supplier No. MAB13097
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Description

Mouse monoclonal antibody raised against synthetic peptide of human AR.

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]

Sequence: STEDTAEYSPFKGGYTK

Specifications

Antigen AR
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SPM335
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic peptide of human AR.
Dilution Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In 1mM PBS (0.05% BSA, 0.05% sodium azide).
Gene Alias AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM
Gene Symbols AR
Host Species Mouse
Immunogen A synthetic peptide corresponding to amino acids 299-315 of human AR.
Purification Method Protein A/G purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 367
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG1 κ
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