Invitrogen™ ARAP1 Monoclonal Antibody (ARAP1-2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119728

Catalog No. MA119728

Description

This antibody reacts with C-terminal part of ARAP1 (intracellular epitope), a 160 kDa adaptor protein.

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

Specifications

• Antigen: ARAP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: Q96P48
• Gene Symbols: Arap1
• Immunogen: His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: ARAP1-2
• Conjugate: Unconjugated
• Gene: Arap1
• Gene Alias: 2410002L19Rik; arap1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin, delta 2; centaurin-delta-2; Centd2; cnt-d2; Kiaa0782; mKIAA0782
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 116985
• Content And Storage: 4°C, do not freeze
• Form: Liquid