Invitrogen™ ARAP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521742

Catalog No. PIPA521742

Description

Recommended positive controls: A431, H1299, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.

Specifications

• Antigen: ARAP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arap1
• Gene Alias: 2410002L19Rik; arap1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin, delta 2; centaurin-delta-2; Centd2; cnt-d2; Kiaa0782; mKIAA0782
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116985
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96P48
• Gene Symbols: Arap1
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1388 and 1450 of ARAP1 (Uniprot ID#Q96P48).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG