Invitrogen™ ARAP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523326

Catalog No. PIPA523326

Description

ARAP2 Polyclonal Antibody for Western Blot, IHC (P)

ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.

Specifications

• Antigen: ARAP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARAP2
• Gene Alias: Arap2; Arf and Rho GAP adapter protein 2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; centaurin; centaurin, delta 1; centaurin-delta-1; CENTD1; Cnt-d1; Gm148; KIAA0580; mKIAA0580; PARX; PARX protein; Protein PARX
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 116984
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: Q8WZ64
• Gene Symbols: ARAP2
• Immunogen: A portion of amino acids 1670-1704 of human ARAP2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG