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Invitrogen™ ARAP2 Polyclonal Antibody
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Catalog No. PIPA523326
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100 μg
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Catalog No. Quantity
PIPA523326 100 μg
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Catalog No. PIPA523326 Supplier Invitrogen™ Supplier No. PA523326
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Description

Rabbit Polyclonal Antibody

The amino acid sequence used as immunogen is 87% homologous in Mouse and Rat, 81% homologous in Canine.

ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARAP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene ARAP2
Gene Accession No. Q8WZ64
Gene Alias Arap2; Arf and Rho GAP adapter protein 2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; centaurin; centaurin, delta 1; centaurin-delta-1; CENTD1; Cnt-d1; Gm148; KIAA0580; mKIAA0580; PARX; PARX protein; Protein PARX
Gene Symbols ARAP2
Host Species Rabbit
Immunogen A portion of amino acids 1670-1704 of human ARAP2.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116984
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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