Invitrogen™ ARC Polyclonal Antibody

Catalog No.	Quantity
PIPA5120251	100 μL

Catalog No. PIPA5120251 Supplier Invitrogen™ Supplier No. PA5120251

Description

Rabbit Polyclonal Antibody

Positive test controls include: SW620, Mouse heart. The target is usually found in the following locations: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus, Sarcoplasmic reticulum, nucleolus. Immunogen sequence: MGNAQERPSE TIDRERKRLV ETLQADSGLL LDALLARGVL TGPEYEALDA LPDAERRVRR LLLLVQGKGE AACQELLRCA QRTAGAPDPA WDWQHVGPGY RDRSYDPPCP GHWTPEAPGS GTTCPGLPRA SDPDEAGGPE GSEAVQSGTP EEPEPELEAE ASKEAEPEPE PEPELEPEAE AEPEPELEPE PDPEPEPDFE ERDESEDS.

ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical.

Specifications

• Antigen: ARC
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.48 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: NOL3
• Gene Accession No.: O60936, Q9D1X0
• Gene Alias: activity regulated cytoskeletal-associated protein; activity regulated cytoskeleton associated protein; activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein; activity-regulated gene 3.1 protein homolog; Apoptosis repressor with CARD; ARC; arc {ECO:0000312; ARC/ARG3.1; Arc3.1; Arg3.1; B430311C09Rik; C86064; FCM; hArc; KIAA0278; mArc; Muscle-enriched cytoplasmic protein; MYC; MYP; Nol3; NOP; Nop 30; Nop30; Nucleolar protein 3; nucleolar protein 3 (apoptosis repressor with CARD domain); nucleolar protein of 30 kDa; rg3.1; RGD:62037}
• Gene Symbols: NOL3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human NOL3 (NP_003937.1).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 78688, 8996
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG