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Tocris Bioscience™ ARCC 4
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Catalog No. 72545
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72-545 5 mg
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Catalog No. 72-545 Supplier Tocris Bioscience™ Supplier No. 7254/5
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Description

Potent and selective androgen receptor PROTAC™

ARCC 4 is a potent and selective androgen receptor (AR) PROTAC™ Degrader (DC50 = 5 nM). Comprises an androgen receptor antagonist, enzalutamide, joined by a linker to a VHL E3 ligase ligand. Brings about degradation of ARs in VCaP and LNCaP prostate cancer cell lines (Dmax = 98% at 12h) in a proteasome-dependent manner, and inhibits cell proliferation. Also degrades clinically relevant AR mutants expressed in HEK293T cells. Exhibits no significant effect on glucocorticoid, estrogen or progesterone receptors at concentrations inducing AR degradation.

ARCC 4 negative control (Cat. No. 7255) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

Chemical Name or Material (2 S,4 R)-1-(-2-(2-(4-((4 '-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1 '-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxami
CAS 1973403-00-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C53H56F3N7O7S2
Purity 0.98
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