Arginase 1/ARG1/liver Arginase Mouse anti-Human, Clone: ARG1/1125, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP247998A	Novus Biologicals NBP2479980.1MG	0.1 mg
NBP247998B	Novus Biologicals NBP2479980.2MG	0.2 mg

Description

Arginase 1/ARG1/liver Arginase Monoclonal specifically detects Arginase 1/ARG1/liver Arginase in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.

Specifications

• Antigen: Arginase 1/ARG1/liver Arginase
• Concentration: 1.0 mg/mL
• Applications: Western Blot, Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence, CyTOF
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Cancer, Cellular Markers, Chromatin Research, Lipid and Metabolism, Myeloid derived Suppressor Cell
• Formulation: PBS with No Preservative
• Gene ID (Entrez): 383
• Immunogen: Recombinant fragment (87 Amino acid residues around aa 1-150) of human ARG1 protein
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Molecular Weight of Antigen: 36.5 kDa

• Clone: ARG1/1125
• Dilution: Western Blot : 0.5 - 1.0 ug/ml, Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin : 2 - 4 ug/ml, Immunofluorescence : 1 - 2 ug/ml, CyTOF-ready
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: arginase 1, arginase, liver, arginase-1, EC 3.5.3.1, Liver-type arginase, Type I arginase
• Gene Symbols: ARG1
• Isotype: IgG3 κ
• Purification Method: Protein A or G purified
• Test Specificity: Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.