Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. Invitrogen™ Arginase 1 Monoclonal Antibody (A1exF5), Brilliant Violet™ 421, eBioscience™, Invitrogen™ 

Invitrogen™ Arginase 1 Monoclonal Antibody (A1exF5), Brilliant Violet™ 421, eBioscience™, Invitrogen™

Catalog No. 404369780
Encompass_Preferred
Change view
Click to view available options
Quantity:
100 μg
25 μg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
40-436-9780 25 μg
40-436-9782 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Catalog No. 40-436-9780 Supplier Invitrogen™ Supplier No. 404369780
Only null left
Add to Cart
Add to Cart

Description

Rat Monoclonal Antibody

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Arginase 1
Applications Flow Cytometry
Classification Monoclonal
Clone A1exF5
Concentration 0.2 mg/mL
Conjugate Brilliant Violet 421
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene ARG1
Gene Accession No. P05089, Q61176
Gene Alias AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Gene Symbols ARG1
Host Species Rat
Immunogen E.coli-derived recombinant mouse Arginase 1.
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11846, 383
Target Species Human, Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
Show More Show Less

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.