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Arginase 1 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody
Supplier: Bioss BS8585R

Description
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.Specifications
Arginase 1 | |
Polyclonal | |
Unconjugated | |
ARG1 | |
AI; A-I; AI type I arginase; AI256583; ARG1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; Arginase-1; BOS_9785; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; Type 1 Arginase; Type I arginase | |
Rabbit | |
Protein A | |
RUO | |
383 | |
-20°C | |
Liquid |
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
1 μg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH | |
P05089 | |
ARG1 | |
KLH conjugated synthetic peptide derived from human Arginase 1. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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