Invitrogen™ ARHGAP22 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595800

Catalog No. PIPA595800

Description

Immunogen sequence: NVPAPGLVPG IPSVASMAWS GASSSESSVG GSLSSCTACR ASDSSARSSL HTDWALEPSP LPSSSEDPKS LDLDHSMDEA GAGASNSEPS EPDSPTREHA RRSEALQGLV TELRAELCRQ RTEYERSVKR IEEGSADLRK R; Positive Samples: Mouse kidney, Mouse lung, Rat kidney, Rat lung; Cellular Location: Cytoplasm, Nucleus.

GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events.

Specifications

• Antigen: ARHGAP22
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arhgap22
• Gene Alias: Arhgap22; B230341L19Rik; p68RacGAP; RHG22; Rho GTPase activating protein 22; rho GTPase-activating protein 22; RHOGAP2; RhoGap22; Rho-type GTPase-activating protein 22
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 239027, 306279
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BL80
• Gene Symbols: Arhgap22
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 510-650 of human ARHGAP22 (NP_0012429531).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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