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Invitrogen™ ARHGAP24 Polyclonal Antibody
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Catalog No. PIPA553140
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100 μL
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PIPA553140 100 μL
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Catalog No. PIPA553140 Supplier Invitrogen™ Supplier No. PA553140
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSD Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGAP24
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ARHGAP24
Gene Accession No. Q8N264
Gene Alias 0610025G21Rik; Arhgap24; Down-regulated in nephrectomized rat kidney #2; DR-NR#2; Filamin-A-associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RCGAP72; RC-GAP72; Rho GTPase activating protein 24; rho GTPase-activating protein 24; rhoGAP of 73 kDa; Rho-type GTPase-activating protein 24; Sarcoma antigen NY-SAR-88; si:ch211-65i12.2
Gene Symbols ARHGAP24
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ARHGAP24. Recombinant protein control fragment (Product #RP-89843).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83478
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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