Invitrogen™ ARHGAP24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553140

Catalog No. PIPA553140

Description

Immunogen sequence: ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSD Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Specifications

• Antigen: ARHGAP24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGAP24
• Gene Alias: 0610025G21Rik; Arhgap24; Down-regulated in nephrectomized rat kidney #2; DR-NR#2; Filamin-A-associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RCGAP72; RC-GAP72; Rho GTPase activating protein 24; rho GTPase-activating protein 24; rhoGAP of 73 kDa; Rho-type GTPase-activating protein 24; Sarcoma antigen NY-SAR-88; si:ch211-65i12.2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 83478
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8N264
• Gene Symbols: ARHGAP24
• Immunogen: Recombinant protein corresponding to Human ARHGAP24. Recombinant protein control fragment (Product #RP-89843).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov