Invitrogen™ ARHGAP24 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA568313

Catalog No. PIPA568313

Description

Predicted to react with Mouse and Rat samples.

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Specifications

• Antigen: ARHGAP24
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGAP24
• Gene Alias: 0610025G21Rik; Arhgap24; Down-regulated in nephrectomized rat kidney #2; DR-NR#2; Filamin-A-associated RhoGAP; FILGAP; p73; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RCGAP72; RC-GAP72; Rho GTPase activating protein 24; rho GTPase-activating protein 24; rhoGAP of 73 kDa; Rho-type GTPase-activating protein 24; Sarcoma antigen NY-SAR-88; si:ch211-65i12.2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 231532, 305156, 83478
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q5U2Z7, Q8C4V1, Q8N264
• Gene Symbols: ARHGAP24
• Immunogen: Synthesized peptide derived from human ARHGAP24.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov