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Invitrogen™ ARHGEF1 Polyclonal Antibody
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Catalog No. PIPA5101844
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100 μL
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PIPA5101844 100 μL
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Catalog No. PIPA5101844 Supplier Invitrogen™ Supplier No. PA5101844
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ARHGEF1.

The Ras superfamily of GTPases, which can be subdivided into the Ras, Rho/Rac, Sar, Rab, ARF and Ran subfamilies, controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). The Dbl-related proteins are a large family of structurally related molecules that have a common ability to catalyze GEF activity for specific members of the Ras family. Dbl-related proteins include FGD1, Lsc, RhoGEF p115, Lfc, Lbc and Brx. Lsc, Lbc and Lfc share sequence homology and show exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42 or Ras GTPases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Arhgef1
Gene Accession No. Q61210, Q92888, Q9Z1I6
Gene Alias 115 kDa guanine nucleotide exchange factor; 115-kD protein; ARHGEF1; GEF1; LBCL2; Lbc's second cousin; Lsc; Lsc homolog; lymphoid blast crisis like 2; lymphoid blast crisis-like 2; p115RhoGEF; p115-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 1; Rho guanine nucleotide exchange factor 1; Sub1.5
Gene Symbols Arhgef1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ARHGEF1(Accession Q92888), corresponding to amino acid residues R161-D211.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16801, 60323, 9138
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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