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Invitrogen™ ARHGEF11 Polyclonal Antibody
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Catalog No. PIPA552897
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100 μL
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PIPA552897 100 μL
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Catalog No. PIPA552897 Supplier Invitrogen™ Supplier No. PA552897
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PGHTMETQAA QEPEDDLTPT PSVISVTSHP WDPGSPGQAP PGGEGDNTQL AGLEGERPEQ EDMGLCSLEH LPPRTRNSGI WESPELDRNL AEDASSTEAA GGYKVVRKAE VAGSKVVPAL P Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 62%.

ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF11
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ARHGEF11
Gene Accession No. O15085
Gene Alias Arhgef11; B930073M02; E130307F09; glutamate transporter EAAT4 associated protein 48; glutamate transporter EAAT4-associated protein 48; Gtrap48; KIAA0380; mKIAA0380; PDZ-RhoGEF; Prg; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF; RhoGEF glutamate transport modulator; RhoGEF glutamate transport modulator GTRAP48; RP11-356J7.2
Gene Symbols ARHGEF11
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ARHGEF11. Recombinant protein control fragment (Product #RP-89159).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9826
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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