Invitrogen™ ARHGEF17 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552498

Catalog No. PIPA552498

Description

Immunogen sequence: VYQREAGHFW DPQNFKSVTL GTQGSPITKM VSVGGRLWCG CQNRVLVLSP DTLQLEHMFY VGQDSSRCVA CMVDSSLGVW VTLKGSAHVC LYHPDTFEQL AEVDVTPPVH RMLAGSDAII RQHKAACLRI TALLVCEELL W Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

Specifications

• Antigen: ARHGEF17
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGEF17
• Gene Alias: 164 kDa Rho-specific guanine-nucleotide exchange factor; 8030463K16; AI428794; Arhgef17; AW558066; BC035332; Kiaa0337; mKIAA0337; P164RHOGEF; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; TEM4; Tumor endothelial marker 4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9828
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96PE2
• Gene Symbols: ARHGEF17
• Immunogen: Recombinant protein corresponding to Human ARHGEF17. Recombinant protein control fragment (Product #RP-100948).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG