Invitrogen™ ARHGEF3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550116

Catalog No. PA550116

Description

The antibody detects endogenous levels of total ARHGEF3 protein.

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: ARHGEF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGEF3
• Gene Alias: 1200004I24Rik; 59.8 kDA protein; 9830169H03Rik; ARHG3; ARHGEF3; C76747; DKFZP434F2429; Exchange factor found in platelets and leukemic and neuronal tissues; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; GEF3; MGC118905; Rho guanine nucleotide exchange factor (GEF) 3; Rho guanine nucleotide exchange factor 3; RhoGEF protein; STA3; Xpln
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50650, 71704
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q91X46, Q9NR81
• Gene Symbols: ARHGEF3
• Immunogen: Synthesized peptide derived from internal of human ARHGEF3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG