Invitrogen™ ARHGEF3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530608

Catalog No. PIPA530608

Description

Recommended positive controls: NT2D1, MCF-7. Predicted reactivity: Mouse (100%), Rat (99%), Zebrafish (87%), Chicken (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: ARHGEF3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGEF3
• Gene Alias: 1200004I24Rik; 59.8 kDA protein; 9830169H03Rik; ARHG3; ARHGEF3; C76747; DKFZP434F2429; Exchange factor found in platelets and leukemic and neuronal tissues; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; GEF3; MGC118905; Rho guanine nucleotide exchange factor (GEF) 3; Rho guanine nucleotide exchange factor 3; RhoGEF protein; STA3; Xpln
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 50650
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9NR81
• Gene Symbols: ARHGEF3
• Immunogen: Recombinant fragment corresponding to a region within amino acids 81 and 337 of Human ARHGEF3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG