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Invitrogen™ ARHGEF7 Polyclonal Antibody
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Catalog No. PIPA5101849
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PIPA5101849 100 μL
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Catalog No. PIPA5101849 Supplier Invitrogen™ Supplier No. PA5101849
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ARHGEF7.

The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF7
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Arhgef7
Gene Accession No. O55043, Q14155, Q9ES28
Gene Alias ARHGEF7; betaPix; Beta-Pix; betaPix-b; betaPix-c; Cool; COOL1; cool-1; KIAA0142; mKIAA0142; Nbla10314; P50; P50BP; p85; p85Cool1; p85SPR; PAK3; Pak3 binding protein; Pak3bp; PAK-interacting exchange factor beta; PIX; Pixb; PIXbeta; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF7); Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Gene Symbols Arhgef7
Host Species Rabbit
Immunogen A synthesized peptide derived from human ARHGEF7(Accession Q14155), corresponding to amino acid residues N311-Y361.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114559, 54126, 8874
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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