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Invitrogen™ ARHGEF7 Polyclonal Antibody
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Catalog No. PIPA588071
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100 μL
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PIPA588071 100 μL
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Catalog No. PIPA588071 Supplier Invitrogen™ Supplier No. PA588071
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP LQTSEKLSSA; Positive Samples: SW620, Jurkat, COS-1, COS-7, MCF7, K-562, Mouse lung, Mouse heart; Cellular Location: Cell junction, Cell projection, Cytoplasm, cell cortex, focal adhesion, lamellipodium, ruffle.

The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF7
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Arhgef7
Gene Accession No. Q14155, Q9ES28
Gene Alias ARHGEF7; betaPix; Beta-Pix; betaPix-b; betaPix-c; Cool; COOL1; cool-1; KIAA0142; mKIAA0142; Nbla10314; P50; P50BP; p85; p85Cool1; p85SPR; PAK3; Pak3 binding protein; Pak3bp; PAK-interacting exchange factor beta; PIX; Pixb; PIXbeta; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF7); Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Gene Symbols Arhgef7
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ARHGEF7 (NP_0011069841).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54126, 8874
Target Species Human, Mouse, Non-human Primate
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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