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MilliporeSigma™ ARHGEF9, Mouse, Unlabeled, Clone: 4D7.1,

Catalog No. MABN1571MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABN1571MI 100 μL Unconjugated
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Catalog No. MABN1571MI Supplier MilliporeSigma™ Supplier No. MABN1571
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Description

Mouse Monoclonal Antibody

Rho guanine nucleotide exchange factor 9 (UniProt O43307; also known as Collybistin, PEM-2 homolog, Rac/Cdc42 guanine nucleotide exchange factor 9) is encoded by the ARHGEF9 (also known as ARHDH9, EIEE8, KIAA0424) gene (Gene ID 23229) in human. Guanine nucleotide exchange factors (GEFs) are cytoplasmic proteins that activate GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). ARHGEF9 acts as a specific GEF for CDC42 and promotes formation of GPHN clusters. In the brain tissue it interacts with the receptor-anchoring protein gephyrin to activate dc42, which is known to regulate actin cytoskeleton dynamics. Its binding to gephyrin can also modulate GABAergic and glycinergic neurotransmission at the synapse. Abnormalities in its expression have been linked to epileptic encephalopathy, early infantile, 8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARHGEF9
Applications Western Blot
Classification Monoclonal
Clone 4D7.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene ARHGEF9, ARHDH9, EIEE8, KIAA0424
Gene Accession No. O43307
Host Species Mouse
Immunogen GST-tagged human ARHGEF9 C-terminal fragment.
Purification Method Protein G Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_056000
Test Specificity Clone 4D7.1 targets ARHGEF9 C-terminal region present in human isoforms 1/2/3 and mouse isoforms 1/2/4 reported by UniProt (O43307 and Q3UTH8). Reactivity toward mouse isoform 3 is not expected.
Target Species Mouse
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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