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Invitrogen™ ARL3 Polyclonal Antibody
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Catalog No. PIPA5106310
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PIPA5106310 100 μL
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Catalog No. PIPA5106310 Supplier Invitrogen™ Supplier No. PA5106310
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ARL3.

ADP-ribosylation factors (ARFs) are low molecular weight GTP-binding proteins belonging to the RAS superfamily. The predicted 182-amino acid ARL3 (ADP-ribosylation like factor) protein shares 97% amino acid identity with rat ARLl3 and 43% identity with human ARF1. Like the ARFs, ARL3 has a glycine at position 2, the site of N myristoylation, and lacks cysteine residues near the C terminus, which are found in other members of the RAS family. Northern blot analysis detected a 1-kb ARL3 transcript in all tissues tested, with highest expression in heart and lung, and lower expression in brain, liver, kidney, ovary, and testis. A 5.5-kb transcript was also detected in most tissues, with highest expression in brain. Immunoblot analysis detected ARL3 in human tumor cell lines but not in normal rodent cells. Although ARL3 binds GTP, it is devoid of activity in the cholera toxin-dependent ADP-ribosylation of Gs, and is therefore classified as an ARF-like protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ARL3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Arl3
Gene Accession No. P36405, P37996, Q9WUL7
Gene Alias ADP ribosylation factor like GTPase 3; ADP-ribosylation factor like GTPase 3; ADP-ribosylation factor-like 3; ADP-ribosylation factor-like protein 3; ADP-ribosylation-like 3; ARD3; ARFL3; ARF-like 3; Arf-like protein 3; Arl3
Gene Symbols Arl3
Host Species Rabbit
Immunogen A synthesized peptide derived from human ARL3(Accession P36405), corresponding to amino acid residues I139-K182.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 403, 56350, 64664
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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