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Tocris Bioscience™ ArMan

Catalog No. 88692
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88-692 2 mg
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Catalog No. 88-692 Supplier Tocris Bioscience™ Supplier No. 8869/2
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Description

DC-SIGN ligand used to target dendritic cells

ArMan is an aryl mannoside targeting ligand that can be functionalised to the surface of virus like particles (VLPs) via click chemistry. Functionalised particles can be used to target DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) dendritic cells to promote selective coengagement of DC-SIGN and TLR7, resulting in a Th1-type immune response. In vivo, immunization with VLP-ArMan-OvaI/II significantly inhibits tumor growth in a murine melanoma model.

Specifications

Chemical Name or Material N-(4-(((2R,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenethyl)pent-4-ynamide
Quantity 2 mg
Target Buffers, Chelators and Reagents
Molecular Formula C19H25NO7
Purity 98%
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