Invitrogen™ ARMER Polyclonal Antibody

Catalog No.	Quantity
PIPA520061	100 μg

Catalog No. PIPA520061 Supplier Invitrogen™ Supplier No. PA520061

Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse small intestine tissue lysate. PA5-20061 can be used with blocking peptide PEP-0180.

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Specifications

• Antigen: ARMER
• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: ARL6IP1
• Gene Accession No.: Q15041, Q9JKW0
• Gene Alias: ADP ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1-like protein; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; AIP1; aip-1; AIP-6; AL022945; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Arl6ip; arl6ip protein; Arl6ip1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; Protein TBX2; SPG61; zgc:56593; zgc:77873
• Gene Symbols: ARL6IP1
• Host Species: Rabbit
• Immunogen: A peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
• Purification Method: Ion-exchange chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23204, 54208
• Target Species: Human, Mouse
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG