Invitrogen™ ARMER Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520061

Catalog No. PIPA520061

Description

A suggested positive control is mouse small intestine tissue lysate. PA5-20061 can be used with blocking peptide PEP-0180.

Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

Specifications

• Antigen: ARMER
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARL6IP1
• Gene Alias: ADP ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1-like protein; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; AIP1; aip-1; AIP-6; AL022945; apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Arl6ip; arl6ip protein; Arl6ip1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; Protein TBX2; SPG61; zgc:56593; zgc:77873
• Host Species: Rabbit
• Purification Method: Ion-exchange chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23204, 54208
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q15041, Q9JKW0
• Gene Symbols: ARL6IP1
• Immunogen: A peptide corresponding to 15 amino acids near the C-terminus of human ARMER.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG