Invitrogen™ ARNT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536283

Catalog No. PIPA536283

Description

This antibody detects endogenous protein at a molecular weight of 79 kDa. Purity is >95% by SDS-PAGE.

AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common PAS motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.

Specifications

• Antigen: ARNT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arnt2
• Gene Alias: Ah receptor nuclear translocator; Arnt; ARNT 2; ARNT protein 2; Arnt2; arnt2a; ARNT2b; ARNT2c; arnt2X; Aryl hydrocarbon receptor nuclear translocator 2; aryl hydrocarbon receptor nuclear translocator 2A; aryl hydrocarbon receptor nuclear translocator type 2a; aryl hydrocarbon receptor nuclear translocator type 2b; aryl hydrocarbon receptor nuclear translocator type 2c; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; bHLH-PAS factor ARNT2B; chunp6921; Class E basic helix-loop-helix protein 1; Hif-2b; KIAA0307; mKIAA0307; unm t30256; unm_t30256; WEDAS; zfARNT2; zfARNT2a; zfARNT2b; zfARNT2c
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11864, 25243, 9915
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q61324, Q78E60, Q9HBZ2
• Gene Symbols: Arnt2
• Immunogen: Synthetic peptide corresponding to amino acids 20-69 of human ARNT2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG