ARNT2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5109413

Catalog No. PIPA5109413

Description

Immunogen sequence: QLQQQQAELE VHQRDGLSSY DLSQVPVPNL PAGVHEAGKS VEKADAIFSQ ERDPRFAEMF AGISASEKKM MSSASAAGTQ QIYSQGSPFP SGHSGKAFSS SVVHVPGVND IQSSSSTGQN MSQISRQLNQ SQVAWTGSRP PFPGQQIPSQ SSKTQSSPFG IGTSHTYPAD PSSYSPLSSP ATSSPSGNAY SSLANRTPGF AESGQSSGQF QGRPSEVWSQ WQSQHHGQQS GEQHSHQQPG QTEVFQDMLP M

AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "e;PAS"e; motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.

Specifications

• Antigen: ARNT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Arnt2
• Gene Alias: Ah receptor nuclear translocator; Arnt; ARNT 2; ARNT protein 2; Arnt2; arnt2a; ARNT2b; ARNT2c; arnt2X; Aryl hydrocarbon receptor nuclear translocator 2; aryl hydrocarbon receptor nuclear translocator 2A; aryl hydrocarbon receptor nuclear translocator type 2a; aryl hydrocarbon receptor nuclear translocator type 2b; aryl hydrocarbon receptor nuclear translocator type 2c; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; bHLH-PAS factor ARNT2B; chunp6921; Class E basic helix-loop-helix protein 1; Hif-2b; KIAA0307; mKIAA0307; unm t30256; unm_t30256; WEDAS; zfARNT2; zfARNT2a; zfARNT2b; zfARNT2c
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11864, 25243
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.55 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q61324, Q78E60
• Gene Symbols: Arnt2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 440-690 of human ARNT2 (NP_055677.3).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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