Invitrogen™ Aromatase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA519633

Catalog No. PIPA519633

Description

Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with rabbit based on sequence homology.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.

Specifications

• Antigen: Aromatase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cyp19a1
• Gene Alias: Ar; ArKO; ARO; ARO1; Arom; Aromatase; aromatase 1; aromatase cytochrome P450; aromatase cytochrome P450 19A1; CPV1; CYAR; Cyp19; Cyp19a; Cyp19a1; CYP19P1; CYPXIX; CYPXIXA1; Cytochrome P450 17-alpha; cytochrome P450 19 type I; Cytochrome P450 19A1; cytochrome P450 aromatase; cytochrome P-450 aromatase; cytochrome P-450 aromatase (alt.); cytochrome P450 family 19 subfamily a; cytochrome P450 family 19 subfamily A member 1; Cytochrome P450, 19, aromatase; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, family 19, subfamily A, polypeptide 1; cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase; cytochrome P450, family19, subfamily A, polypeptide 1; cytochrome P450, subfamily 19; cytochrome P450, subfamily XIX (aromatization of androgens); cytochrome P-450AROM; estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; Int5; Int-5; MGC104309; microsomal monooxygenase; P450AROM; P-450AROM; type III cytochrome p450 aromatase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1588, 494003
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunohistochemistry (PFA fixed)
• Concentration: 0.3 mg/mL
• Formulation: PBS with 1% BSA and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P11511, Q5QQX7
• Gene Symbols: Cyp19a1
• Immunogen: Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of Human Aromatase.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Canine
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov